When a one-night stand that should have stayed that way has unexpected consequences, the reluctant odd couple attempts to transform their tentative relationship into a lasting love in this conception comedy. Twenty-four-year-old entertainment journalist Alison Scott (Katherine Heigl) is on the fast track to the big time, but an alcohol-fueled hookup with responsibility-shirking slacker Ben Stone (Seth Rogen) finds her professional priorities taking a back seat to having a baby.